BREAKING NEWS: Wall Street Journal article puts spotlight on the potential of new anticoagulants taking fresh aim at one of cardiology’s toughest challenges.

February 9, 2023

Evaluating Evolving Approaches to Treating Thrombosis in Cancer

 

Accredited CME Program

MODERATOR

Jean M. Connors, MD
Medical Director, Hemostatic Antithrombotic Stewardship
Medical Director, Anticoagulation Management Services (Hematology Division)
Brigham and Women’s Hospital/Dana-Farber Cancer Institute
Associate Professor of Medicine
Harvard Medical School
Boston, Massachusetts, United States

 

FACULTY

FACULTY

AlokA. Khorana, MD
Professor of Medicine
Cleveland Clinic Lerner College of Medicine
Case Western Reserve University
Sondra and Stephen Hardis Chair in Oncology Research
Vice Chair, Clinical Services
Director, Gl Malignancies Program
Taussig Cancer Institute
Cleveland Clinic
Cleveland, Ohio, United States
Jeffrey l. Weitz, MD, FRCP(C), FACP, FCCP
Professor of Medicine and Biochemistry
McMaster University
Hamilton, Ontario, Canada

 

Slide presentation: Evaluating Evolving Approaches to Treating Thrombosis in Cancer SLIDE

 

Burden of Cancer-Associated Thrombosis

 

Cancer-Associated Thrombosis = Arterial Venous Thrombosis

 

Mechanism of Thrombosis is Different in Cancer Patients

 

Choosing Between the Agents

 

CLOT Trial and the FDA-Approved LMWHs

 

Choosing Between the Agents

 

Choosing Between the Agents

 

Guideline Recommendations for Treatment of CAT-VTE

 

Weighing the Treatment Options

 

Considerations for Anticoagulation Therapy in Cancer Patients

 

The CARAVAGGIO Study

 

Finding the Right Therapy

 

Treatment Individualization and Shared Decisions

 

Though LMWH Is Preferred for High Risk of Bleeding…
Adherence/Treatment Persistence is an Issue

 

Limitations of Standard Care

Data from RCTs Comparing DOACs and LMWH in CAT

Why Target Factor XI?
Anticoagulants, Hemostasis, and Thrombosis

 

FXI
Uncoupling Thrombosis From Hemostasis

 

Targeting the Instrinsic Pathway

 

Clotting Cascade
Factor XI Targets

 

Phase 3 Clinical Trials Targeting Factor XI for CAT

 

Emerging Clinical Trials Targeting Factor XI – Phase 3

 

Other Studies Targeting Factor XI

 

FXI
Uncoupling Thrombosis from Homeostasis: Future Uses

 

Concluding Remarks