About Anthos Therapeutics

Anthos Therapeutics is a transformative, clinical-stage biopharmaceutical company dedicated to developing innovative therapeutic options for the treatment of cardiovascular metabolic diseases, founded by Blackstone Life Sciences (BXLS). Our initial focus is on the advancement of a novel anticoagulant therapy to address critical unmet needs in patients who require a safer treatment option.

Our Factor XI inhibitor, abelacimab, is in late-stage clinical trials for the prevention and treatment of arterial and venous thromboembolism in patients with atrial fibrillation and cancer associated thrombosis. Abelacimab has received Fast Track Designations from the Food and Drug Administration (FDA) for both disease areas. Through cutting-edge research and patient-centric solutions, we aim to redefine the anticoagulation treatment landscape and improve the lives of those in need.

Anthos Therapeutics, or “ἄνθος”, is an ancient Greek word meaning “flower” or “blossom.” We chose this name because it reflects our mission – to develop innovative therapies that enhance people’s quality of life and help them thrive. For us, it symbolizes hope and the potential for positive change that we can bring to people’s lives.

OUR MISSION

At Anthos Therapeutics, our mission is to redefine cardiovascular care with pioneering therapies that inspire hope and healing for patients and their caregivers. We are committed to pushing the boundaries of innovation, addressing critical unmet needs in vulnerable populations with urgency, and striving for unparalleled excellence across all aspects of our work. Our immediate goal is to establish a new benchmark in anticoagulation treatment to improve the lives of patients worldwide.  

Careers
at Anthos Therapeutics

Anthos Therapeutics is led by a world-class executive team highly experienced in the successful development, approval, and commercialization of products across a wide range of therapeutic areas.

Bill Meury is the Chief Executive Officer and a member of the Board of Directors of Anthos Therapeutics. Bill brings significant expertise in strategic planning, commercialization, business development and licensing, R&D partnerships and new product launches. Read more

Our Board of Directors has extensive experience in development and commercialization, with proven success in innovation and growth. Their strategic vision drives our continued excellence.

Scott Beardsley

Managing Partner, Novo Holdings

Ari Brettman, MD

Senior Managing Director, Blackstone Life Sciences

Raymond Camahort, PhD 

Partner, Novo Holdings
Anthos Therapeutics Board Observer

Nicholas Galakatos, PhD 

Global Head, Blackstone Life Sciences
Chairman, Board of Directors, Anthos Therapeutics

Bill Meury 

Chief Executive Officer, Anthos Therapeutics

Paris Panayiotopoulos 

Senior Managing Director, Blackstone Life Sciences

Peter Renehan, MD 

Principal, Blackstone Life Sciences
Anthos Therapeutics Board Observer

Vasilisa (Vaska) Sazonov, M.Pharm, MSc, PhD 

Head of Cardiovascular-Renal-Metabolic Commercial Team, Novartis International
Anthos Therapeutics Board Observer

Milestones & Achievements

Anthos Therapeutics was founded with a strategic commitment to develop and commercialize innovative therapies for patients with a high unmet need.

  • Anthos Therapeutics was launched by Blackstone Life Sciences after it obtained the exclusive global rights to develop, manufacture, and commercialize the factor XI inhibitor, abelacimab, a fully human monoclonal antibody.

  • A study published in the Journal of the American Society of Hematology – Blood concluded that abelacimab is a novel, fully human, factor XI antibody that exhibits strong and long-lasting anticoagulant activity in humans with a promising safety profile.

  • Anthos Therapeutics named to Fierce Biotech’s 2019 Fierce 15.

  • Anthos Therapeutics ranked #2 in BioSpace’s “NextGen Bio” Class of 2020.

  • In a Phase 2 study published in the New England Journal of Medicine (NEJM), authors concluded that a single post-operative dose of abelacimab reduced the rate of venous thromboembolism (VTE) by 80% compared to enoxaparin and was associated with a low risk of bleeding.

  • An article published in the Journal of the American College of Cardiology (JACC) highlighted that although currently available anticoagulants are effective, bleeding is the most frequent side effect and that factor XI inhibitors may serve as hemostasis-sparing anticoagulants with better safety profiles.

  • A study published in the Journal of Thrombosis and Hemostasis (JTH) investigating the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of abelacimab in both healthy volunteers and patients with atrial fibrillation, demonstrated that abelacimab produced rapid factor XI (FXI) inhibition with a greater than 99% reduction in free FXI levels and profoundly suppressed it for four weeks, in a safe and well-tolerated manner.

  • Abelacimab becomes the first Factor XI inhibitor to enroll patients in a Phase 3 trial.

  • ASTER Phase 3 trial begins enrolling patients to compare abelacimab relative to apixaban on venous thromboembolism (VTE) recurrence and bleeding in patients with cancer associated VTE.

  • FDA grants Fast Track Designation to abelacimab for the treatment of thrombosis associated with cancer.

  • MAGNOLIA Phase 3 study begins enrolling patients to compare abelacimab to dalteparin in the treatment of gastrointestinal/​genitourinary cancer and associated VTE.

  • FDA grants Fast Track Designation to abelacimab for the prevention of stroke and systemic embolism in patients with atrial fibrillation.

  • LILAC-TIMI 76 Phase 3 study begins to enroll patients with atrial fibrillation deemed unsuitable for current anticoagulants.

  • Regulatory authorities in China and Japan approve registrational trials for abelacimab.

  • AZALEA-TIMI 71 Phase 2 study stopped early by the independent data monitor committee (IDMC) because of a substantially greater than anticipated reduction in major and clinically relevant non-major bleeds in with abelacimab as compared to rivaroxaban.

  • With an overall benefit:risk favoring abelacimab, the IDMC also recommended that an optional open-label extension period should be made available so that all eligible patients could benefit from abelacimab therapy.

  • Landmark AZALEA-TIMI 71 Phase 2 study presented as a late-breaker at the American Heart Association (AHA) 2023 Scientific Congress, showed that abelacimab had a 67% reduction in major or clinically relevant non-major bleeding compared with rivaroxaban in patients with atrial fibrillation. Secondary endpoints also showed a highly significant 74% reduction in major bleeding and a 93% reduction in gastrointestinal (GI) bleeding with abelacimab. The study also showed that abelacimab 150mg dosed once-monthly achieved a near complete 99% inhibition of factor XI.

  • Bill Meury is appointed as CEO.

  • First-ever cost-effective analysis of a factor XI inhibitor demonstrates that abelacimab could offer significant cost savings on a per-patient basis and higher quality-adjusted life years in atrial fibrillation patients at high risk of stroke compared to rivaroxaban.

  • In the open-label extension of the AZALEA-TIMI 71 Phase 2 study, 84% of eligible patients in the open-label voluntarily transitioned to abelacimab, including 75% of rivaroxaban patients.