About Anthos Therapeutics
Our Factor XI inhibitor, abelacimab, is in late-stage clinical trials for the prevention and treatment of arterial and venous thromboembolism in patients with atrial fibrillation and cancer associated thrombosis. Abelacimab has received Fast Track Designations from the Food and Drug Administration (FDA) for both disease areas. Through cutting-edge research and patient-centric solutions, we aim to redefine the anticoagulation treatment landscape and improve the lives of those in need.
Anthos Therapeutics, or “ἄνθος”, is an ancient Greek word meaning “flower” or “blossom.” We chose this name because it reflects our mission – to develop innovative therapies that enhance people’s quality of life and help them thrive. For us, it symbolizes hope and the potential for positive change that we can bring to people’s lives.
OUR MISSION
At Anthos Therapeutics, our mission is to redefine cardiovascular care with pioneering therapies that inspire hope and healing for patients and their caregivers. We are committed to pushing the boundaries of innovation, addressing critical unmet needs in vulnerable populations with urgency, and striving for unparalleled excellence across all aspects of our work. Our immediate goal is to establish a new benchmark in anticoagulation treatment to improve the lives of patients worldwide.
Careers
at Anthos Therapeutics
Scott Beardsley
Managing Partner, Novo HoldingsAri Brettman, MD
Senior Managing Director, Blackstone Life SciencesRaymond Camahort, PhD
Partner, Novo HoldingsAnthos Therapeutics Board Observer
Nicholas Galakatos, PhD
Global Head, Blackstone Life SciencesChairman, Board of Directors, Anthos Therapeutics
Bill Meury
Chief Executive Officer, Anthos TherapeuticsParis Panayiotopoulos
Senior Managing Director, Blackstone Life SciencesPeter Renehan, MD
Principal, Blackstone Life SciencesAnthos Therapeutics Board Observer
Vasilisa (Vaska) Sazonov, M.Pharm, MSc, PhD
Head of Cardiovascular-Renal-Metabolic Commercial Team, Novartis InternationalAnthos Therapeutics Board Observer
Milestones & Achievements
Anthos Therapeutics was founded with a strategic commitment to develop and commercialize innovative therapies for patients with a high unmet need.
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2019
Anthos Therapeutics was launched by Blackstone Life Sciences after it obtained the exclusive global rights to develop, manufacture, and commercialize the factor XI inhibitor, abelacimab, a fully human monoclonal antibody.
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A study published in the Journal of the American Society of Hematology – Blood concluded that abelacimab is a novel, fully human, factor XI antibody that exhibits strong and long-lasting anticoagulant activity in humans with a promising safety profile.
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2021
In a Phase 2 study published in the New England Journal of Medicine (NEJM), authors concluded that a single post-operative dose of abelacimab reduced the rate of venous thromboembolism (VTE) by 80% compared to enoxaparin and was associated with a low risk of bleeding.
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An article published in the Journal of the American College of Cardiology (JACC) highlighted that although currently available anticoagulants are effective, bleeding is the most frequent side effect and that factor XI inhibitors may serve as hemostasis-sparing anticoagulants with better safety profiles.
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2022
A study published in the Journal of Thrombosis and Hemostasis (JTH) investigating the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of abelacimab in both healthy volunteers and patients with atrial fibrillation, demonstrated that abelacimab produced rapid factor XI (FXI) inhibition with a greater than 99% reduction in free FXI levels and profoundly suppressed it for four weeks, in a safe and well-tolerated manner.
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ASTER Phase 3 trial begins enrolling patients to compare abelacimab relative to apixaban on venous thromboembolism (VTE) recurrence and bleeding in patients with cancer associated VTE.
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FDA grants Fast Track Designation to abelacimab for the treatment of thrombosis associated with cancer.
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MAGNOLIA Phase 3 study begins enrolling patients to compare abelacimab to dalteparin in the treatment of gastrointestinal/genitourinary cancer and associated VTE.
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FDA grants Fast Track Designation to abelacimab for the prevention of stroke and systemic embolism in patients with atrial fibrillation.
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2023
LILAC-TIMI 76 Phase 3 study begins to enroll patients with atrial fibrillation deemed unsuitable for current anticoagulants.
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AZALEA-TIMI 71 Phase 2 study stopped early by the independent data monitor committee (IDMC) because of a substantially greater than anticipated reduction in major and clinically relevant non-major bleeds in with abelacimab as compared to rivaroxaban.
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With an overall benefit:risk favoring abelacimab, the IDMC also recommended that an optional open-label extension period should be made available so that all eligible patients could benefit from abelacimab therapy.
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Landmark AZALEA-TIMI 71 Phase 2 study presented as a late-breaker at the American Heart Association (AHA) 2023 Scientific Congress, showed that abelacimab had a 67% reduction in major or clinically relevant non-major bleeding compared with rivaroxaban in patients with atrial fibrillation. Secondary endpoints also showed a highly significant 74% reduction in major bleeding and a 93% reduction in gastrointestinal (GI) bleeding with abelacimab. The study also showed that abelacimab 150mg dosed once-monthly achieved a near complete 99% inhibition of factor XI.
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First-ever cost-effective analysis of a factor XI inhibitor demonstrates that abelacimab could offer significant cost savings on a per-patient basis and higher quality-adjusted life years in atrial fibrillation patients at high risk of stroke compared to rivaroxaban.
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In the open-label extension of the AZALEA-TIMI 71 Phase 2 study, 84% of eligible patients in the open-label voluntarily transitioned to abelacimab, including 75% of rivaroxaban patients.